Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Imidazole ketone erastin (IKE) is an iron death inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has antitumor activity and induces glutathione depletion and lipid peroxidation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 172.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 392.00 | |
50 mg | In stock | $ 596.00 | |
100 mg | In stock | $ 787.00 | |
500 mg | In stock | $ 1,580.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 192.00 |
Description | Imidazole ketone erastin (IKE) is an iron death inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has antitumor activity and induces glutathione depletion and lipid peroxidation. |
In vitro |
METHODS: Human astrocytoma cells CCF-STTG1 were incubated with Imidazole ketone erastin for 2 h. Glutamate released into the medium was detected using glutamate oxidase, horseradish peroxidase, and Amplex UltraRed fluorimetric assay. RESULTS: The IC50 for system xc- inhibition by Imidazole ketone erastin was 30 nM. [1] METHODS: 18 DLBCL cell lines were treated with Imidazole ketone erastin (0.0001-100 µM) for 24 h. Cell viability was measured using the Cell Titor-Glo luminescent cell viability test. RESULTS: DLBCL cell lines showed different sensitivities to Imidazole ketone erastin inhibition. 7 cell lines with IC50 <100 nM were categorized as sensitive; 5 cell lines with IC50 >10 µM were categorized as resistant; and 6 cell lines with IC50 between 100 nM and 10 µM were categorized as moderately resistant. [2] |
In vivo |
METHODS: To detect anti-tumor activity in vivo, Imidazole ketone erastin (23-40 mg/kg, 5% DMSO in HBSS at pH 4) was injected intraperitoneally into NCG mice harboring human diffuse histiocytic lymphoma SUDHL6 once daily for thirteen days. RESULTS: Imidazole ketone erastin inhibited tumor growth in vivo. [2] METHODS: To test the antitumor activity in vivo, Imidazole ketone erastin (40 mg/kg every two days) and liproxstatin-1 (10 mg/kg once a day) were intraperitoneally injected into C57BL/6 mice with the hepatocellular carcinoma tumor Hepa1-6 for ten days on either a control (Met+) or a methionine-free (Met-) diet. Met-) diet. RESULTS: In mice receiving the control diet, Imidazole ketone erastin treatment effectively reduced tumor growth, and this effect was completely blocked by liproxtatin-1. However, in mice receiving a methionine-free diet, Imidazole ketone erastin treatment failed to inhibit tumor growth. [3] |
Synonyms | IKE |
Molecular Weight | 655.14 |
Formula | C35H35ClN6O5 |
CAS No. | 1801530-11-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (152.64 mM)
You can also refer to dose conversion for different animals. More
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Imidazole ketone erastin 1801530-11-9 Apoptosis Ferroptosis IKE inhibitor inhibit